On the Mechanism of Hydrolysis of β-Acetal Cobalamins
Silverman, R.B. and David Dolphin
J. Am. Chem. Soc.
The cobalamin acetals (1,3-dioxa-2-cyclopentylmethyl)cobalamin and (2,2-diethoxyethyl)cobalamin decompose by hydrolysis to (formylmethyl)cobalamin (I) and by direct Co-C bond fission. I also undergoes Co-C bond cleavage to MeCHO and B12b.