Pub No:
63
Title:
The Direct Knorr Synthesis of 2-Pyrrolecarboxamides
Authors:
Paine, J.B. and David Dolphin
Journal:
J. Heterocycl. Chem.
Year:
1975
Pages:
12, 1317-1318
Abstract:
MeCOCH2CONEt2 and MeCOCH2CONMe2 were nitrosated with NaNO2 in AcOH and the resulting oximinoacetoacetamides treated with MeCOCH2COMe or MeCOCHMeCOMe under Knorr conditions to give pyrroles I [R = Ac, Me, R1 = Et; R = R1 = Me (II)]. II was oxidized with Pb(OAc)4 and the product treated with CH2 (CN) 2 in the presence of MeNH2 to give N,N-dimethyl-5-(2,2-dicyanovinyl)-3,4-dimethylpyrrole-2-carboxamide.

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