Metalloporphyrins as Chemical Mimics of Cytochrome P-450 Systems
Chorghade, M.S., Dezaro, D.A., Hill, D.R., Lee, E.C., Pariza, R.J., Andersen, J.V., Hansen, K.T., and David Dolphin
Bioorganic and Medicinal Chemistry
A review with 21 references, of synthetic metalloporphyrins that have been shown to mimic the in vivo metabolism of pharmaceuticals by cytochrome P 450. Oxidation, hydroxylation and N-demethylation reactions are discussed. If found to be general, this lays the foundation of a predictive basis to optimize analog design of inhibitors with reduced oxidative reactivity, to determine the proclivity of drugs to form biologically active metabolites, and provides a convenient methodology for their preparation.