Photomedicine and Photodynamic Therapy
Can. J. Chem.
1993 Syntex Award Lecture A review with 47 references. Photodynamic therapy (PDT) involves the treatment of diseased tissue and cells using a photosensitizer and visible light. Such photo medical treatments have been known since the time of the ancient Egyptians but it was only just this year that this therapeutic modality was made available to modern medicine with the approval, in Canada, of Photofrin for the treatment of bladder cancer. This pare reviews PDT with an emphasis on drug development, particularly for the second generation drugs, esp. BPDMA (benzoporphyrin derivative mono acid), which is now in human clinical trials.