Pub No:
23
Title:
A Convenient and Economical Preparation of L-Methionine-methyl-d3
Authors:
David Dolphin and Endo, K.
Journal:
Anal. Biochem.
Year:
1970
Pages:
36, 338-342
Abstract:
The thermal decomposition of nonadeuterio trimethylsulfoxonium iodide, prepared from the nondeuterated salt and deuterium oxide, gives a high yield of methyl-d3 iodide. Direct alkylation of the L-homocysteine anion, generated by sodium-liquid ammonia reduction of L-methionine, by methyl- d3 iodide gives optically pure L-methionine-methyl- d3. A procedure for the preparation of tritiated compdounds was also developed.

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