PATENT DETAILS

Patent ID:
52
Inventors:
David Dolphin, Christian Bruckner
Title:
Methods to Prepare B,B'-Dihydroxy Meso-Substituted Chlorins, Isobacteriochlorins and Bacteriochlorins
Country:
United States
Patent No:
5831088
Grant Date:
1998-11-03
Abstract:
Title compounds were prepared by osmylating a β,β'-unsubstituted, meso-substituted porphyrin to form an osmate ester at the β,β'-position and reducing the osmate ester to form the title compound. The compounds are useful in photodynamic therapy (no data). Thus meso-tetraphenylporphyrin was osmylated and reduced with H2S to give the dihydroxy derivative in 49% yield.

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